Document Detail

Colonic expression of Runx3 protein and TGF-β(1) and their correlation in patients with irritable bowel syndrome.
MedLine Citation:
PMID:  21803306     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.
METHODS: Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.
RESULTS: Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).
CONCLUSIONS: The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.
Xiaoning Sun; Cheng Lan; Yu An; Ye Sun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of tropical medicine     Volume:  4     ISSN:  1995-7645     ISO Abbreviation:  Asian Pac J Trop Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101533720     Medline TA:  Asian Pac J Trop Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  547-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou 570311, China.
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