Document Detail

Colon electrical stimulation: potential use for treatment of obesity.
MedLine Citation:
PMID:  21660079     Owner:  NLM     Status:  MEDLINE    
Obesity is one of the most prevalent health problems in the United States. Current therapeutic strategies for the treatment of obesity are unsatisfactory. We hypothesized the use of colon electrical stimulation (CES) to treat obesity by inhibiting upper gastrointestinal motility. In this preliminary study, we aimed at studying the effects of CES on gastric emptying of solid, intestinal motility, and food intake in dogs. Six dogs, equipped with serosal colon electrodes and a jejunal cannula, were randomly assigned to receive sham-CES or CES during the assessment of: (i) gastric emptying of solids, (ii) postprandial intestinal motility, (iii) autonomic functions, and (iv) food intake. We found that (i) CES delayed gastric emptying of solids by 77%. Guanethidine partially blocked the inhibitory effect of CES on solid gastric emptying; (ii) CES significantly reduced intestinal contractility and the effect lasted throughout the recovery period; (iii) CES decreased vagal activity in both fasting and fed states, increased the sympathovagal balance and marginally increased sympathetic activity in the fasting state; (iv) CES resulted in a reduction of 61% in food intake. CES reduces food intake in healthy dogs and the anorexigenic effect may be attributed to its inhibitory effects on gastric emptying and intestinal motility, mediated via the autonomic mechanisms. Further studies are warranted to investigate the therapeutic potential of CES for obesity.
Hanaa S Sallam; Jiande D Z Chen
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Publication Detail:
Type:  Journal Article     Date:  2011-06-09
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-05-07     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1761-7     Citation Subset:  IM    
Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA.
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MeSH Terms
Adrenergic Antagonists / pharmacology
Appetite Regulation*
Autonomic Nervous System / drug effects
Cecum / innervation,  physiology
Colon / drug effects,  innervation,  physiology,  physiopathology*
Electric Stimulation / methods
Electric Stimulation Therapy*
Gastric Emptying / drug effects
Gastrointestinal Motility* / drug effects
Gastrointestinal Transit
Guanethidine / pharmacology
Obesity / physiopathology,  therapy*
Postprandial Period
Random Allocation
Serous Membrane / innervation,  physiology
Sympathetic Nervous System / physiology
Vagus Nerve / physiology
Reg. No./Substance:
0/Adrenergic Antagonists; 55-65-2/Guanethidine

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