Document Detail


Colon electrical stimulation: potential use for treatment of obesity.
MedLine Citation:
PMID:  21660079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is one of the most prevalent health problems in the United States. Current therapeutic strategies for the treatment of obesity are unsatisfactory. We hypothesized the use of colon electrical stimulation (CES) to treat obesity by inhibiting upper gastrointestinal motility. In this preliminary study, we aimed at studying the effects of CES on gastric emptying of solid, intestinal motility, and food intake in dogs. Six dogs, equipped with serosal colon electrodes and a jejunal cannula, were randomly assigned to receive sham-CES or CES during the assessment of: (i) gastric emptying of solids, (ii) postprandial intestinal motility, (iii) autonomic functions, and (iv) food intake. We found that (i) CES delayed gastric emptying of solids by 77%. Guanethidine partially blocked the inhibitory effect of CES on solid gastric emptying; (ii) CES significantly reduced intestinal contractility and the effect lasted throughout the recovery period; (iii) CES decreased vagal activity in both fasting and fed states, increased the sympathovagal balance and marginally increased sympathetic activity in the fasting state; (iv) CES resulted in a reduction of 61% in food intake. CES reduces food intake in healthy dogs and the anorexigenic effect may be attributed to its inhibitory effects on gastric emptying and intestinal motility, mediated via the autonomic mechanisms. Further studies are warranted to investigate the therapeutic potential of CES for obesity.
Authors:
Hanaa S Sallam; Jiande D Z Chen
Related Documents :
18409419 - Habitat saturation drives thresholds in stream subsidies.
16040699 - Web-spinning caterpillar stalks snails.
17503589 - Trophic levels and trophic tangles: the prevalence of omnivory in real food webs.
19789709 - The origin and initial rise of pelagic cephalopods in the ordovician.
14642899 - Pulling the other one: 1st- and 2nd-order visual information interact to determine perc...
2391049 - Vertebrate predation in cebus capucinus: meat eating in a neotropical monkey.
2824159 - Levels of arsenic in indian opium eaters.
2200589 - Isotope fractionation by plants and animals: implications for nutrition research.
23363999 - Food sources of energy and nutrients among adults in the us: nhanes 2003–2006.
Publication Detail:
Type:  Journal Article     Date:  2011-06-09
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-05-07     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1761-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic Antagonists / pharmacology
Animals
Appetite Regulation*
Autonomic Nervous System / drug effects
Cecum / innervation,  physiology
Colon / drug effects,  innervation,  physiology,  physiopathology*
Dogs
Electric Stimulation / methods
Electric Stimulation Therapy*
Female
Gastric Emptying / drug effects
Gastrointestinal Motility* / drug effects
Gastrointestinal Transit
Guanethidine / pharmacology
Obesity / physiopathology,  therapy*
Postprandial Period
Random Allocation
Serous Membrane / innervation,  physiology
Sympathetic Nervous System / physiology
Vagus Nerve / physiology
Chemical
Reg. No./Substance:
0/Adrenergic Antagonists; 55-65-2/Guanethidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat.
Next Document:  Identification of overweight in children in the United States: a simplified approach.