| Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. | |
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MedLine Citation:
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PMID: 20112993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pomegranate juice derived ellagitannins and their intestinal bacterial metabolites, urolithins, inhibited TCDD-induced CYP1-mediated EROD activity in vitro with IC(50) values ranging from 56.7 microM for urolithin A to 74.8 microM for urolithin C. These compounds exhibited dose- and time-dependent decreases in cell proliferation and clonogenic efficiency of HT-29 cells. Inhibition of cell proliferation was mediated through cell cycle arrest in the G(0)/G(1) and G(2)/M stages of the cell cycle followed by induction of apoptosis. These results indicate that the ellagitannins and urolithins released in the colon upon consumption of pomegranate juice in considerable amounts could potentially curtail the risk of colon cancer development, by inhibiting cell proliferation and inducing apoptosis. |
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Authors:
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Sashi G Kasimsetty; Dobroslawa Bialonska; Muntha K Reddy; Guoyi Ma; Shabana I Khan; Daneel Ferreira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 2180-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacognosy, Research Institute for Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Annexin A5
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analysis Apoptosis / drug effects Beverages Cell Cycle / drug effects Cell Division / drug effects Colon / drug effects, physiology Colonic Neoplasms / pathology, prevention & control* HT29 Cells / drug effects*, pathology Humans Hydrolyzable Tannins / chemical synthesis, isolation & purification*, therapeutic use Methylene Blue / isolation & purification*, therapeutic use Propidium Punicaceae / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Hydrolyzable Tannins; 36015-30-2/Propidium; 61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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