| Colombian Experience with Transcatheter Aortic Valve Implantation of Medtronic CoreValve. | |
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MedLine Citation:
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PMID: 22719143 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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At our institutions, increasing numbers of aortic stenosis patients were not candidates for surgical aortic valve replacement. Accordingly, we initiated the Cali Colombian Transcatheter Aortic Valve Implantation (TAVI) program. From March 2008 through January 2011, 53 consecutive patients (mean age, 79 ± 6 yr; men, 58%) underwent TAVI with the Medtronic CoreValve System, and data were prospectively collected. Our study's endpoints conformed with Valve Academic Research Consortium recommendations. We report our clinical results.Predicted mortality rates were 25% (interquartile range, 17%-34%) according to logistic EuroSCORE and 6% (interquartile range, 3%-8%) according to the Society of Thoracic Surgeons score. The 30-day mortality rate was 9% (3 intraprocedural deaths, 5 total). The combined 30-day safety endpoint was 30% (major vascular sequelae, 23%; life-threatening bleeding, 12%; myocardial infarction, 4%; major stroke, 4%; and acute kidney injury [stage 3], 2%). Eight patients (15%) required post-implantation balloon dilation and 2 (4%) required valve-in-valve implantation, for a technical device success rate of 77%. Mean peak transvalvular gradient decreased from 74 ± 29 to 17 ± 8 mmHg and mean transvalvular gradient from 40 ± 17 to 8 ± 4 mmHg (both P=0.001). Moderate or severe aortic regurgitation decreased from 32% to 18% (P=0.12) and mitral regurgitation from 32% to 13% (P=0.002). The 1-year survival rate was 81%.We found that TAVI with the CoreValve prosthesis was safe and feasible, with sustained long-term results, for treating aortic stenosis in patients at excessive surgical risk; nonetheless, serious adverse events occurred in 30% of the patients. |
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Authors:
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Antonio E Dager; Rutger-Jan Nuis; Bernardo Caicedo; Jaime A Fonseca; Camilo Arana; Lidsa Cruz; Luis M Benitez; Carlos A Nader; Eduardo Duenas; Eduardo J de Marchena; William W O'Neill; Peter P de Jaegere |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital Volume: 39 ISSN: 1526-6702 ISO Abbreviation: - Publication Date: 2012 |
Date Detail:
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Created Date: 2012-6-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214622 Medline TA: Tex Heart Inst J Country: - |
Other Details:
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Languages: ENG Pagination: 351-358 Citation Subset: - |
Affiliation:
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: Department of Cardiology (Drs. Arana, Caicedo, Dager, and Fonseca, and Ms Cruz), Angiografia de Occidente, Cali, Colombia; Departments of Echocardiography (Drs. Benitez and Nader) and Cardio-Vascular Surgery (Dr. Duenas), Clinica de Occidente, Cali, Colombia; Department of Cardiology (Dr. de Jaegere and Mr. Nuis), Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands; and Cardiovascular Division (Drs. Dager, de Marchena, and O'Neill), Miller School of Medicine, University of Miami, Miami, Florida 33136. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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