| Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma. | |
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MedLine Citation:
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PMID: 8593263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Verruciform xanthoma is a rare variant of xanthoma that appears predominantly on oral mucosa and the anogenital area. The histologic features are characterized by marked accumulation of foam cells in the papillary dermis with verrucous epidermal acanthosis and hyperkeratosis. However, little is known of the nature or origin of foam cells. Recent studies have emphasized the crucial role of macrophage scavenger receptors in the formation of foam cells in atherogenesis. We examined the immunohistologic localization of scavenger receptors in genital verruciform xanthoma. We found that the massively infiltrated foam cells in the papillary dermis were CD68+ monocyte-macrophage lineage cells, and that the majority of CD68+ cells coexpressed scavenger receptors. The in situ staining pattern of scavenger receptor in foam cells was mainly of an intracytoplasmic vacuolar pattern similar to that of dermal resident macrophages found in normal skin. Furthermore, CD1a+ Langerhans cells, completely negative for scavenger receptor, were markedly decreased in number in verruciform xanthoma. These results indicate that scavenger receptor-bearing CD68+ cells are also actively involved in the development of cutaneous verruciform xanthoma, as has been shown to be the case in atherogenesis. |
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Authors:
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M Furue; H Suzuki; T Kodama; T Hiramoto; H Sugiyama; K Tamaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of dermatological science Volume: 10 ISSN: 0923-1811 ISO Abbreviation: J. Dermatol. Sci. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-04-09 Completed Date: 1996-04-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9011485 Medline TA: J Dermatol Sci Country: IRELAND |
Other Details:
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Languages: eng Pagination: 213-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Yamanashi Medical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies / analysis Antigens, CD / analysis* Antigens, CD1 / analysis Antigens, Differentiation, Myelomonocytic / analysis* Fluorescent Antibody Technique Foam Cells / immunology, metabolism* Humans Male Membrane Proteins* Receptors, Immunologic / immunology, metabolism* Receptors, Lipoprotein* Receptors, Scavenger Scavenger Receptors, Class B Skin Diseases / immunology, metabolism* Tissue Distribution Xanthomatosis / immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, CD; 0/Antigens, CD1; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Membrane Proteins; 0/Receptors, Immunologic; 0/Receptors, Lipoprotein; 0/Receptors, Scavenger; 0/Scarb1 protein, mouse; 0/Scavenger Receptors, Class B |
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