Document Detail

Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice.
MedLine Citation:
PMID:  19071193     Owner:  NLM     Status:  MEDLINE    
A recent study has demonstrated that the G-protein coupled receptor GPR120 is expressed in the taste bud cells in rats. In this study, we have identified the types of taste cell that express GPR120 in C57/BL6 mice. Double immunostaining for GPR120 and the markers of type II taste cells (phospholipase-Cbeta2 and alpha-gustducin) revealed that the majority of the GPR120-positive taste cells are type II taste cells. In contrast, it was observed that GPR120 was rarely colocalized with the marker of type III cells (neuronal cell adhesion molecule). These results suggested that GPR120 is mainly expressed in the type II taste cells and might function as a sensor for dietary fat.
Shigenobu Matsumura; Ai Eguchi; Takafumi Mizushige; Nobuhide Kitabayashi; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-03
Journal Detail:
Title:  Neuroscience letters     Volume:  450     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-24     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Oiwakecho, Kitashirakawa, Sakyo-ku, Kyoto, 606-8502, Japan.
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MeSH Terms
Gene Expression / physiology
Mice, Inbred C57BL
Neural Cell Adhesion Molecules / metabolism
Neurons / classification,  metabolism*
Phospholipase C beta / genetics,  metabolism*
RNA, Messenger / metabolism
Receptors, G-Protein-Coupled / genetics,  metabolism*
Taste Buds / cytology*
Transducin / genetics,  metabolism*
Reg. No./Substance:
0/Neural Cell Adhesion Molecules; 0/O3far1 protein, mouse; 0/RNA, Messenger; 0/Receptors, G-Protein-Coupled; 147979-21-3/Gnat3 protein, rat; EC C beta; EC protein, mouse; EC 3.6.1.-/Transducin

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