| Colloid volume loading does not mitigate decreases in central blood volume during simulated hemorrhage while heat stressed. | |
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MedLine Citation:
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PMID: 22219334 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Heat stress results in profound reductions in the capacity to withstand a simulated hemorrhagic challenge; however, this capacity is normalized if the individual is volume loaded prior to the challenge. The present study tested the hypothesis that volume loading during passive heat stress attenuates the reduction in regional blood volumes during a simulated hemorrhagic challenge imposed via lower-body negative pressure (LBNP). Seven subjects underwent 30 mmHg LBNP while normothermic, during passive heat stress (increased internal temperature ~1°C), and while continuing to be heated after intravenous colloid volume loading (11 ml/kg). Relative changes in torso and regional blood volumes were determined by gamma camera imaging with technetium-99m labeled erythrocytes. Heat stress reduced blood volume in all regions (ranging from 7 to 16%), while subsequent volume loading returned those values to normothermic levels. While normothermic, LBNP reduced blood volume in all regions (torso: 22±8%; heart: 18±6%; spleen: 15±8%). During LBNP while heat stressed, the reductions in blood volume in each region were markedly greater when compared to LBNP while normothermic (torso: 73±2%; heart: 72±3%; spleen: 72±5%, all P<0.001 relative to normothermia). Volume loading during heat stress did not alter the extent of the reduction in these blood volumes to LBNP relative to heat stress alone (torso: 73±1%; heart: 72±2%; spleen: 74±3%, all P>0.05 relative to heat stress alone). These data suggest that blood volume loading during passive heat stress (via 11 ml/kg of a colloid solution) normalizes regional blood volumes in the torso, but does not mitigate the reduction in central blood volume during a simulated hemorrhagic challenge combined with heat stress. |
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Authors:
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Craig G Crandall; Thad E Wilson; Jens Marving; Morten Bundgaard-Nielsen; Thomas Seifert; Thomas Klausen; Flemming Andersen; Niels Secher; Birger Hesse |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-4 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Texas Southwestern Medical Center at Dallas; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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