Document Detail

Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip.
MedLine Citation:
PMID:  18399808     Owner:  NLM     Status:  MEDLINE    
We report on a case of the collision of a desmoplastic-neurotropic melanoma and a squamous cell carcinoma on the lip. A 46-year-old male developed a multifocal infiltrative squamous cell carcinoma of the lower lip, which also showed sparse melanocyte atypia within the epidermis and an extensive spindle cell proliferation within the dermis, subcutaneous tissues and nerves. An immunohistochemical panel showed that the spindle cells were melanocytes, not derived from the squamous cell carcinoma. Double labeling with AE1/AE3 and S100 showed striking localized proximity of the spindle-cell melanocytic and keratinocyte components in some areas of this tumor. To our knowledge, this is the first report of the collision of a squamous cell carcinoma and desmoplastic-neurotropic melanoma.
Vincent Falanga; Molly Chartier; Janet Butmarc; Lance Tibbetts
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  35     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  473-6     Citation Subset:  IM    
Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA.
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MeSH Terms
Carcinoma, Squamous Cell / chemistry,  pathology*,  therapy
Cell Proliferation
Combined Modality Therapy
Fibrosis / pathology
Immunoenzyme Techniques
Keratinocytes / chemistry,  pathology
Lip Neoplasms / chemistry,  pathology*,  therapy
Melanocytes / chemistry,  pathology
Melanoma / chemistry,  pathology*,  therapy
Middle Aged
Neoplasms, Multiple Primary / pathology*,  therapy
Skin Neoplasms / chemistry,  pathology*,  therapy
Tumor Markers, Biological / analysis
Grant Support
Reg. No./Substance:
0/Tumor Markers, Biological

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