| Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404. | |
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MedLine Citation:
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PMID: 18503191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis. |
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Authors:
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Azusa Aoyagi; Mariko Ito-Kobayashi; Yasunori Ono; Yoji Furukawa; Mizuki Takahashi; Yasunori Muramatsu; Megumi Umetani; Toshio Takatsu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 61 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-10-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 136-41 Citation Subset: IM |
Affiliation:
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Advanced Technology Research Laboratories, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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11-beta-Hydroxysteroid Dehydrogenase Type 1
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antagonists & inhibitors* 11-beta-Hydroxysteroid Dehydrogenase Type 2 / antagonists & inhibitors Chemistry, Physical Colletotrichum / chemistry*, classification Crystallography, X-Ray Cyclopentanes / chemistry, pharmacology* Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology* Esters / chemical synthesis Fermentation Humans Kinetics Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Physicochemical Phenomena Spiro Compounds / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclopentanes; 0/Enzyme Inhibitors; 0/Esters; 0/Spiro Compounds; 0/colletoic acid; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 1; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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