Document Detail

Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy.
MedLine Citation:
PMID:  12012455     Owner:  NLM     Status:  MEDLINE    
We present well-resolved absorption spectra of biological molecules in the far-IR (FIR) spectral region recorded by terahertz time-domain spectroscopy (THz-TDS). As an illustrative example we discuss the absorption spectra of benzoic acid, its monosubstitutes salicylic acid (2-hydroxy-benzoic acid), 3- and 4-hydroxybenzoic acid, and aspirin (acetylsalicylic acid) in the spectral region between 18 and 150 cm(-1). The spectra exhibit distinct features originating from low-frequency vibrational modes caused by intra- or intermolecular collective motion and lattice modes. Due to the collective origin of the observed modes the absorption spectra are highly sensitive to the overall structure and configuration of the molecules, as well as their environment. The THz-TDS procedure can provide a direct fingerprint of the molecular structure or conformational state of a compound.
M Walther; P Plochocka; B Fischer; H Helm; P Uhd Jepsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biopolymers     Volume:  67     ISSN:  0006-3525     ISO Abbreviation:  Biopolymers     Publication Date:  2002  
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372525     Medline TA:  Biopolymers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-3     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley Periodicals, Inc.
Department of Molecular and Optical Physics, Fakultät für Physik, Albert-Ludwigs Universität Freiburg, Stefan-Meier-Strasse 19, Germany.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Aspirin / chemistry
Benzoic Acid / chemistry
Hydroxybenzoic Acids / chemistry
Parabens / chemistry
Protein Conformation
Salicylic Acid / chemistry
Spectrophotometry / methods*
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Hydroxybenzoic Acids; 0/Parabens; 50-78-2/Aspirin; 65-85-0/Benzoic Acid; 69-72-7/Salicylic Acid; 99-06-9/3-hydroxybenzoic acid

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