Document Detail

Collective cell migration of the cephalic neural crest: The art of integrating information.
MedLine Citation:
PMID:  21157935     Owner:  NLM     Status:  Publisher    
The cephalic neural crest cells delaminate from the neuroepithelium in large numbers and undergo collective cell migration under the influence of multiple factors including positive and negative taxis, cell-cell interactions mediating cell sorting, cell cooperation and contact-inhibition of locomotion. The migration has to be tightly regulated to allow neural crest cells to reach precise locations in order to contribute to various craniofacial structures such as the skeletal and peripheral nervous systems. Several birth defects, syndromes and malformations are due to improper cephalic neural crest migration and neural crest cell migration bears important similarities to cancer cell invasion and metastasis dissemination. Therefore, understanding how cephalic neural crest cells interpret multiple inputs to achieve directional collective cell migration will shed light on pathological situations where cell migration is involved. © 2010 Wiley-Liss, Inc.
Eric Theveneau; Roberto Mayor
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-14
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  -     ISSN:  1526-968X     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cell and Developmental Biology, University College London, UK.
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