Document Detail


Collective chemotaxis requires contact-dependent cell polarity.
MedLine Citation:
PMID:  20643349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell protrusions promoted by cell contact. At this cell contact, N-cadherin inhibits protrusion and Rac1 activity and in turn promotes protrusions and activation of Rac1 at the free edge. These results show a role for N-cadherin during contact inhibition of locomotion, and they reveal a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis, whereby attractants such as Sdf1 amplify and stabilize contact-dependent cell polarity, resulting in directional collective migration.
Authors:
Eric Theveneau; Lorena Marchant; Sei Kuriyama; Mazhar Gull; Barbara Moepps; Maddy Parsons; Roberto Mayor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  19     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-08-30     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-53     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cadherins / genetics,  physiology
Cell Adhesion / physiology*
Cell Communication / physiology
Cell Polarity / physiology*
Cells, Cultured
Chemokine CXCL12 / genetics,  physiology
Chemotaxis / physiology*
Contact Inhibition / physiology
Embryonic Development / physiology
Models, Biological
Neural Crest / cytology,  embryology
Receptors, CXCR4 / genetics,  physiology
Xenopus / embryology,  genetics,  physiology
Xenopus Proteins / genetics,  physiology
Grant Support
ID/Acronym/Agency:
G0801145//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Cadherins; 0/Chemokine CXCL12; 0/Receptors, CXCR4; 0/SDF-1 protein, Xenopus; 0/Xenopus Proteins
Comments/Corrections

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