| Collection and processing of mucosal secretions from mice. | |
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MedLine Citation:
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PMID: 21380685 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The major route of transmission of the human immunodeficiency virus type 1 (HIV-1) worldwide, like other agents of sexually transmitted disease, is via mucosal surfaces of the genital tract through sexual exposures (1-4). It has been hypothesized that immune responses at these sites may be important determinants of protection against HIV-1 (1,2,5). Development of HIV-1 vaccines which elicit local mucosal immune responses may be critical for an effective preventive vaccine. Specific mucosal immune responses elicited after different routes of mucosal immunization in rodents have been examined previously (6-16). Nasal and oral immunization routes have elicited strong mucosal responses to HIV-1 peptides and whole proteins in mice (7,11,17,18,24). Induction of mucosal and systemic immunity to SIV and HIV-1 antigens in primates has also been obtained using a variety of mucosal routes of vaccine administration (19-22). |
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Authors:
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R W Kaminski; T C Vancott |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular medicine Volume: 17 ISSN: 1543-1894 ISO Abbreviation: Methods Mol. Med. Publication Date: 1999 |
Date Detail:
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Created Date: 2011-03-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101123138 Medline TA: Methods Mol Med Country: United States |
Other Details:
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Languages: eng Pagination: 329-39 Citation Subset: - |
Affiliation:
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Henry M. Jackson Foundation, Rockville, MD. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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