| Review: Collectins link innate and adaptive immunity in allergic airway disease. | |
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MedLine Citation:
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PMID: 20418258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the lipoprotein complex of pulmonary surfactant has long been recognized as essential for reducing lung surface tension, its role in lung immune host defense has only relatively recently been elucidated. Surfactant-associated proteins A (SP-A) and D (SP-D) can attenuate bacterial and viral infection and inflammation by acting as opsonins and by regulating innate immune cell functions. Surfactant-associated protein A and D also interact with antigen-presenting cells and T cells, thereby linking the innate and adaptive immune systems. A recent study from our laboratory demonstrated that mice deficient in SP-A have enhanced susceptibility to airway hyper-responsiveness and lung inflammation induced by Mycoplasma pneumonia, an atypical bacterium present in the airways of approximately 50% of asthmatics experiencing their first episode, and further supports an important role for SP-A in the host response to allergic airway disease. Animal and human studies suggest that alterations in the functions or levels of SP-A and SP-D are associated with both infectious and non-infectious chronic lung diseases such as asthma. Future studies are needed to elucidate whether alterations in SP-A and SP-D are a consequence and/or cause of allergic airway disease. |
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Authors:
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Julie G Ledford; Amy M Pastva; Jo Rae Wright |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-04-23 |
Journal Detail:
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Title: Innate immunity Volume: 16 ISSN: 1753-4267 ISO Abbreviation: Innate Immun Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-11-03 Revised Date: 2011-09-14 |
Medline Journal Info:
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Nlm Unique ID: 101469670 Medline TA: Innate Immun Country: United States |
Other Details:
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Languages: eng Pagination: 183-90 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity Alveolitis, Extrinsic Allergic Animals Antimicrobial Cationic Peptides / immunology* Asthma / genetics, immunology*, metabolism Bronchial Hyperreactivity Collectins / immunology* Disease Susceptibility Humans Immunity, Innate Inflammation Mice Mice, Knockout Pneumonia, Mycoplasma Pulmonary Surfactant-Associated Protein A / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1K08AI068822/AI/NIAID NIH HHS; 1P01AI81672/AI/NIAID NIH HHS; 2R01HL030923/HL/NHLBI NIH HHS; 5P50HL084917/HL/NHLBI NIH HHS; 5R01HL068072/HL/NHLBI NIH HHS; F32HL091642/HL/NHLBI NIH HHS; K08 AI068822-04/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/Collectins; 0/Pulmonary Surfactant-Associated Protein A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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