Document Detail


Collecting Duct Renin: A major player in Angiotensin II-dependent Hypertension.
MedLine Citation:
PMID:  20046983     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Recently, the focus of interest on the role of the renin angiotensin system in the pathophysiology of hypertension has shifted towards greater emphasis on new developments in local renin angiotensin systems in specific tissues. We have focused our recent investigations on the role of the intrarenal-intratubular RAS in hypertension. All of the components needed for angiotensin II generation are present within the various compartments in the kidney. This brief review is focused on recent evidence that inappropriate activation of renin in distal nephron segments, by acting on angiotensinogen generated in the proximal tubule cells and delivered to the distal nephron may contribute to increased distal intrarenal angiotensin II formation, sodium retention and development and progression of hypertension.
Authors:
Minolfa C Prieto-Carrasquero; Fady T Botros; Hiroyuki Kobori; L Gabriel Navar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  3     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2010-04-22     Completed Date:  2012-10-02     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-104     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P20 RR017659/RR/NCRR NIH HHS; P20 RR017659-03/RR/NCRR NIH HHS; R01 DK072408/DK/NIDDK NIH HHS; R01 DK072408-01A1/DK/NIDDK NIH HHS
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