Document Detail


Collateralization and the response to obstruction of epicardial coronary arteries.
MedLine Citation:
PMID:  15100419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Occlusive coronary disease is an important cause of global morbidity and mortality. While mechanical revascularization is effective, some individuals are not amenable to such interventions, and have a poorer prognosis. However, collateral circulation can protect and preserve myocardium around the time of coronary occlusion, contribute to better residual myocardial contractility, and lessen symptoms. We describe the anatomy and physiology of coronary collateralization, its component parts (angiogenesis and arteriogenesis), the current methods for definition of the collateral response and how this might be manipulated. The manipulation of this process is a realistic possibility for future adjuvant treatment of coronary artery disease.
Authors:
M H Tayebjee; G Y H Lip; R J MacFadyen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  97     ISSN:  1460-2725     ISO Abbreviation:  QJM     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-21     Completed Date:  2004-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-72     Citation Subset:  IM    
Affiliation:
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK.
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MeSH Terms
Descriptor/Qualifier:
Collateral Circulation*
Coronary Circulation
Coronary Stenosis / physiopathology*,  therapy
Exercise / physiology
Humans
Neovascularization, Pathologic
Prognosis

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