| Collateral function modified by glyceryl trinitrate and dipyridamole during coronary occlusion in conscious dogs. | |
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MedLine Citation:
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PMID: 3115584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of glyceryl trinitrate and dipyridamole on induced ischaemia were studied in awake dogs during transient coronary occlusion before and after collateral development. Seventeen dogs were instrumented under sterile conditions with a miniature pressure gauge to measure left ventricular pressure, a cannula for aortic pressure, and pairs of piezoelectric crystals towards the subendocardium of the left ventricle for regional segment length measurements. A hydraulic cuff occluder and Doppler flow probe were placed around the left circumflex coronary artery. Collateral function was increased by repeated 2 min coronary occlusions at 32 min intervals for 2-9 days until regional wall motion returned to preocclusive values, despite the persistence of coronary occlusion. The effects of glyceryl trinitrate and dipyridamole were studied after the initial haemodynamic changes had subsided. Collateral function was quantified by integrating changes in end systolic length of the ischaemic area during coronary occlusion. Before collateral development the end systolic length area was 29.4(2.4) cm X s and was unchanged by glyceryl trinitrate or dipyridamole. After the development of collaterals the end systolic length area decreased from 4.1(1.1) to 2.2(1.0) cm X s (p less than 0.01) after glyceryl trinitrate and increased to 14.9(1.7) cm X s (p less than 0.01) after dipyridamole. Therefore, glyceryl trinitrate acted directly on collaterals and improved the induced ischaemia, whereas dipyridamole exaggerated the regional wall motion abnormality. |
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Authors:
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S Nabeyama; H Tomoike; K Hisano; H Shimokawa; T Inoue; H Yamamoto; M Nakamura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 21 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-11-10 Completed Date: 1987-11-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-87 Citation Subset: IM |
Affiliation:
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Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / physiopathology* Collateral Circulation / drug effects* Coronary Circulation / drug effects Coronary Disease / physiopathology* Coronary Vessels / pathology, physiopathology Dipyridamole / pharmacology* Dogs Hemodynamics / drug effects Nitroglycerin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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