Document Detail


Collateral-flow measurements in humans by myocardial contrast echocardiography: validation of coronary pressure-derived collateral-flow assessment.
MedLine Citation:
PMID:  16207739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Myocardial blood flow (MBF) is the gold standard to assess myocardial blood supply and, as recently shown, can be obtained by myocardial contrast echocardiography (MCE). The aims of this human study are (i) to test whether measurements of collateral-derived MBF by MCE are feasible during elective angioplasty and (ii) to validate the concept of pressure-derived collateral-flow assessment. METHODS AND RESULTS: Thirty patients with stable coronary artery disease underwent MCE of the collateral-receiving territory during and after angioplasty of 37 stenoses. MCE perfusion analysis was successful in 32 cases. MBF during and after angioplasty varied between 0.060-0.876 mL min(-1) g(-1) (0.304+/-0.196 mL min(-1) g(-1)) and 0.676-1.773 mL min(-1) g(-1) (1.207+/-0.327 mL min(-1) g(-1)), respectively. Collateral-perfusion index (CPI) is defined as the rate of MBF during and after angioplasty varied between 0.05 and 0.67 (0.26+/-0.15). During angioplasty, simultaneous measurements of mean aortic pressure, coronary wedge pressure, and central venous pressure determined the pressure-derived collateral-flow index (CFI(p)), which varied between 0.04 and 0.61 (0.23+/-0.14). Linear-regression analysis demonstrated an excellent agreement between CFI(p) and CPI (y=0.88 x +0.01; r(2)=0.92; P<0.0001). CONCLUSION: Collateral-derived MBF measurements by MCE during angioplasty are feasible and proved that the pressure-derived CFI exactly reflects collateral relative to normal myocardial perfusion in humans.
Authors:
Rolf Vogel; Rainer Zbinden; Andreas Indermühle; Stephan Windecker; Bernhard Meier; Christian Seiler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2005-10-05
Journal Detail:
Title:  European heart journal     Volume:  27     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University Hospital Bern, CH-3010 Bern, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity / physiology
Blood Pressure
Collateral Circulation / physiology*
Coronary Artery Disease / physiopathology*,  ultrasonography
Coronary Circulation / physiology*
Coronary Stenosis / physiopathology,  ultrasonography
Echocardiography / standards
Female
Humans
Male
Middle Aged
Comments/Corrections
Comment In:
Eur Heart J. 2006 Jul;27(13):1627; author reply 1627-8   [PMID:  16728423 ]
Eur Heart J. 2006 Jan;27(2):123-4   [PMID:  16319086 ]

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