| Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle. | |
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MedLine Citation:
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PMID: 20618691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Chronic and acute ischemic diseases-peripheral artery disease, coronary artery disease, stroke-result in tissue damage unless blood flow is maintained or restored in a timely manner. Mice of different strains recover from arteriolar ligation (by increasing collateral blood flow) at different speeds. We quantify the spatio-temporal patterns of microvascular network remodeling following arteriolar ligation in different mouse strains to better understand inter-individual variability. METHODS: Whole-muscle spinotrapezius microvascular networks of mouse strains C57Bl/6, Balb/c and CD1 were imaged using confocal microscopy following ligation of feeding arterioles. RESULTS: Baseline arteriolar structures of C57Bl/6 and Balb/c mice feature heavily ramified arcades and unconnected dendritic trees, respectively. This network angioarchitecture identifies ischemia-protected and ischemia-vulnerable tissues; unlike C57Bl/6, downstream capillary perfusion in Balb/c spinotrapezius is lost following ligation. Perfusion recovery requires arterialization (expansion and investment of mural cells) of a subset of capillaries forming a new low-resistance collateral pathway between arteriolar trees. Outbred CD1 exhibit either Balb/c-like or C57Bl/6-like spinotrapezius angioarchitecture, predictive of response to arteriolar ligation. CONCLUSIONS: This collateral capillary arterialization process may explain the reported longer time required for blood flow recovery in Balb/c hindlimb ischemia, as low-resistance blood flow pathways along capillary conduits must be formed ("arterialization") before reperfusion. |
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Authors:
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Feilim Mac Gabhann; Shayn M Peirce |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 17 ISSN: 1549-8719 ISO Abbreviation: Microcirculation Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-29 Revised Date: 2011-06-16 |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 333-47 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. feilim@jhu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / growth & development, pathology Capillaries / growth & development, pathology Collateral Circulation* Disease Models, Animal Female Ischemia / pathology* Ligation Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Microcirculation* Muscle, Skeletal / blood supply* Reperfusion Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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HL082838-02/HL/NHLBI NIH HHS; K99 HL093219-01/HL/NHLBI NIH HHS; K99-HL093219/HL/NHLBI NIH HHS; R00 HL093219-04/HL/NHLBI NIH HHS; R01 HL082838-02/HL/NHLBI NIH HHS; R01 HL082838-03/HL/NHLBI NIH HHS; R01 HL082838-04/HL/NHLBI NIH HHS; R01 HL082838-05/HL/NHLBI NIH HHS; T32 HL007284-32/HL/NHLBI NIH HHS; T32-HL007284/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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