| Collapsing FSGS: a clinicopathologic study of 10 cases from Pakistan. | |
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MedLine Citation:
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PMID: 20224877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Idiopathic collapsing focal segmental glomerulosclerosis (FSGS), a rare variant of FSGS, is of interest because of its increasing incidence, frequent association with black race, HIV-1 infection, and intravenous (IV) drug abuse. This lesion has not been reported from Pakistan until now. METHODS: We reviewed our 14-year native renal biopsies record and identified 10 cases of this entity (July 1995-July 2009). Patients' demographic and clinicopathologic data were collected from case files. Renal biopsies were studied by light microscopy, immunofluorescence microscopy, and electron microscopy. A control group of 124 patients with noncollapsing FSGS was selected for comparison of clinical, laboratory, and outcome parameters. RESULTS: All the patients were young adults (mean age: 22.4 +/- 4.6 years). The majority were males (9 vs. 1 female). All presented with nephrotic syndrome (24-h urinary protein: 6.7 +/- 9.22 g). In addition, 8 had mild to moderate renal failure (serum creatinine: 4.12 +/- 4.6 mg/dl). No history of heroin or IV drug abuse was elicited and all tested negative for HIV. Only two patients (20%) responded to steroid treatment, while eight (80%) did not. Five of the patients (50%) developed endstage renal disease after a mean interval of 18 months. CONCLUSION: Idiopathic collapsing FSGS is increasingly being reported in patients who have no HIV infection or history of IV drug abuse. There is a need for increased awareness among pathologists all over the world to diagnose this condition to guide nephrologists and patients regarding the poor prognosis of this form of FSGS. |
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Authors:
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Muhammed Mubarak; Javed I Kazi |
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Publication Detail:
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Type: Journal Article Date: 2010-03-12 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 14 ISSN: 1437-7799 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 222-7 Citation Subset: IM |
Affiliation:
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Histopathology Department, Sindh Institute of Urology and Transplantation, Karachi, 74200, Pakistan. drmubaraksiut@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Glomerulosclerosis, Focal Segmental / complications, epidemiology, pathology* Humans Kidney Failure, Chronic / etiology Male Nephrotic Syndrome / etiology Pakistan / epidemiology Retrospective Studies |
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