| Collapsibility of the relaxed pharynx and risk of sleep apnoea. | |
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MedLine Citation:
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PMID: 18550611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study measured hypotonic pharyngeal collapsibility in subjects not known to have obstructive sleep apnoea (OSA), and assessed the variables that affect collapsibility and the relationship with OSA. The critical value of positive end-expiratory pressure (P(crit)) was measured under the hypotonic condition of anaesthesia in 227 subjects who underwent elective surgery. The risk of OSA in this population was estimated using the Berlin questionnaire. The mean P(crit) for all subjects was positive (above atmospheric), ranging from 0.69 (95% confidence interval (CI) -7.39-8.77) to 4.0 (CI -4.82-12.82) cmH(2)O for subjects with low and high prevalence of OSA, respectively. P(crit) < or = -5 cmH(2)O was only found in 3.1% of the study subjects. In the general population, P(crit) was similar in males and females and correlated positively with increasing age, while a correlation with neck circumference was found only in males. P(crit )accounted for only 12.25% of the variability in OSA risk score. In conclusion, subjects with high critical value of positive end-expiratory pressure are at an increased risk for developing obstructive sleep apnoea. However, the human pharynx is prone to collapse and occludes in most people in the absence of neuromuscular support. Therefore, in most subjects, the level of neuromuscular activity may ultimately determine the occurrence of sleep apnoea. |
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Authors:
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A Oliven; E Aspandiarov; I Gankin; L Gaitini; N Tov |
Publication Detail:
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Type: Journal Article Date: 2008-06-11 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 32 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1309-15 Citation Subset: IM |
Affiliation:
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Dept of Internal Medicine, Bnai Zion Medical Center, 47 Golomb Str., Haifa, Israel. oliven@tx.technion.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Anesthesia Anthropometry Female Halothane / pharmacology Humans Male Middle Aged Pharynx / anatomy & histology, physiopathology* Pressure Prevalence Propofol / pharmacology Questionnaires Sleep Apnea, Obstructive / diagnosis*, physiopathology |
| Chemical | |
Reg. No./Substance:
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151-67-7/Halothane; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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