Document Detail

Collapse of intercellular spaces of canine tracheal mucosa by epinephrine.
MedLine Citation:
PMID:  3182496     Owner:  NLM     Status:  MEDLINE    
Variations in the volume and width of lateral intercellular spaces (LICS) of dog tracheal mucosa in vitro were investigated by use of stereological and linear measurements of electron micrographs. Alterations in the volume or width of LICS were then correlated with physiological conditions and electrical parameters. LICS were quite narrow between the ciliated cells compared with those around the nonciliated dark cells (goblet, brush, and basal cells). LICS comprised 6.8 +/- 2.9% of tissue volume in preparations that were mounted in an Ussing chamber and short-circuited, whereas in unmounted and open-circuited tissues it occupied only 1 +/- 0.2% of the volume of the preparations (P less than 0.016, n = 5). The effects of stimulation of Cl secretion by 1 microM epinephrine were tested. In seven epinephrine-treated tissues LICS volume was 2.9 +/- 0.9% of total epithelial volume compared with 8.7 +/- 2.9% in control tissues (P less than 0.015). The width of LICS around dark cells in epinephrine-treated tissues was 0.42 +/- 0.06 micron compared with 0.98 +/- 0.13 micron in control tissues (P less than 0.001). The data suggest that LICS act as pliable fluid reservoirs that empty and collapse on stimulation of Cl secretion.
F J al-Bazzaz; J Veech; D Arenberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  65     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-12-07     Completed Date:  1988-12-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1274-80     Citation Subset:  IM    
Department of Medicine, University of Illinois College of Medicine, Chicago.
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MeSH Terms
Biological Transport, Active
Chlorides / metabolism
Epinephrine / pharmacology*
Extracellular Space / drug effects*,  metabolism
Microscopy, Electron
Mucous Membrane / drug effects,  metabolism,  ultrastructure
Trachea / drug effects*,  metabolism,  ultrastructure
Reg. No./Substance:
0/Chlorides; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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