Document Detail

Collagenous gastritis: reports and systematic review.
MedLine Citation:
PMID:  19730387     Owner:  NLM     Status:  MEDLINE    
Collagenous gastritis is a rare disorder first described in 1989. After encountering two cases, we decided to review the literature and evaluate the collagen band. A systematic review of PubMed and EMBASE databases was performed. Twenty-eight cases have been previously described and two patterns of presentations are identifiable: children or young adults (median age 12 years, range 2-22 years) presenting with symptoms attributable to the gastritis (anaemia and pain); and older adults (median age 52 years, range 35-77 years) presenting with loose stools, often associated with collagenous colitis or coeliac disease. Our two cases (one child and one adult) matched this pattern. Immunostaining of the collagen band for collagens II, III, IV and VI, and tenascin showed that the band in our cases was predominantly tenascin. In conclusion, collagenous gastritis is a rare entity whose presentation depends on the age of the patient. An autoimmune aetiology seems possible given its associations. Treatment is empirical. The 30 cases now reported show that the disorder can relapse or persist for years.
Oliver Brain; Chandima Rajaguru; Bryan Warren; Jonathan Booth; Simon Travis
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  21     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-12     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1419-24     Citation Subset:  IM    
John Radcliffe Hospital, Oxford, UK.
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MeSH Terms
Anemia, Iron-Deficiency / etiology
Child, Preschool
Collagen / analysis*
Diarrhea / etiology
Gastritis / complications,  drug therapy,  metabolism*
Middle Aged
Tenascin / analysis
Young Adult
Reg. No./Substance:
0/Tenascin; 9007-34-5/Collagen

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