Document Detail

Collagenous gastritis: a long-term follow-up with the development of endocrine cell hyperplasia, intestinal metaplasia, and epithelial changes indeterminate for dysplasia.
MedLine Citation:
PMID:  11710694     Owner:  NLM     Status:  MEDLINE    
This report reviews the literature pertaining to collagenous gastritis and describes the clinicopathologic evolution of this disease in a patient during a 12-year period. We examined 109 biopsy specimens of gastric mucosa from 19 different endoscopic procedures for the severity and distribution of collagenous gastritis in a single patient. Assessments were undertaken for the presence of endocrine and gastrin cell hyperplasias and dysplastic epithelial changes. Relative to biopsy specimens from age- and sex-matched control subjects, the patient's biopsy specimens showed a significantly lower number of antral gastrin cells, along with a significant corpus endocrine cell hyperplasia, suggesting an increased risk of endocrine neoplasia. Gastric corpus biopsy specimens revealed an active, chronic gastritis, subepithelial collagen deposition, smooth muscle hyperplasia, and mild to moderate glandular atrophy. Additional findings of intestinal metaplasia and reactive epithelial changes indeterminate for dysplasia raise concerns about the potential for adenocarcinoma.
J L Winslow; T D Trainer; R B Colletti
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  116     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-16     Completed Date:  2001-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  753-8     Citation Subset:  AIM; IM    
Department of Pathology, University of Vermont College of Medicine, Burlington 05401, USA.
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MeSH Terms
Adenocarcinoma / pathology
Atrophy / pathology
Cell Count
Chronic Disease
Collagen / analysis*
Follow-Up Studies
Gastrin-Secreting Cells / chemistry,  pathology
Gastritis / metabolism,  pathology*
Immunoenzyme Techniques
Muscle, Smooth / pathology
Neurosecretory Systems / chemistry,  pathology
Precancerous Conditions / pathology
Pyloric Antrum / chemistry,  pathology
Stomach Neoplasms / pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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