Document Detail

Collagenases and cracks in the plaque.
MedLine Citation:
PMID:  23908120     Owner:  NLM     Status:  MEDLINE    
The core of an atheromatous plaque contains lipids, macrophages, and cellular debris, typically covered by a fibrous cap that separates the thrombogenic core from the blood. Rupture of the fibrous cap causes most fatal myocardial infarctions. Interstitial collagen confers tensile strength on the cap, as it does in skin and tendons. In 1994, Peter Libby and colleagues demonstrated overexpression of collagenolytic enzymes in atheromatous plaques and implicated MMPs in the destabilization of these lesions.
Peter Libby
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-08-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-02     Completed Date:  2013-10-22     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3201-3     Citation Subset:  AIM; IM    
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MeSH Terms
Atherosclerosis / complications,  enzymology*
Collagenases / physiology*
Myocardial Infarction / enzymology,  etiology
Plaque, Atherosclerotic / complications,  enzymology*
Grant Support
Reg. No./Substance:
EC 3.4.24.-/Collagenases

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