Document Detail

Collagenase inhibitors from Viola yedoensis.
MedLine Citation:
PMID:  22529049     Owner:  NLM     Status:  Publisher    
Fractionation of acetone and methanol extracts of Viola yedoensis, under the guidance of inhibition against Clostridium histolyticum collagenase (ChC), resulted in the isolation of esculetin (1) (IC(50) 12 μM) and scopoletin (2) (IC(50) 1.8 μM) as the active constituents, together with trans-p-coumaric acid (3), cis-p-coumaric acid (4), 3-O-β-D: -glucosyl-7-O-α-L-rhamnosylkaempferol (5), rutin (6), isovitexin (7), isoorientin (8), vicenin-2 (9), isoscoparin (10), vanillic acid (11) and adenosine (12). Modification of phenolic hydroxy groups of 1 showed that small O-alkyl groups largely increased the activity, whereas larger O-alkyl groups decreased the activity, and 6,7-dimethoxycoumarin (scoparone 13) potently inhibited ChC (IC(50) 24 nM).
Naohiro Oshima; Yuji Narukawa; Tadahiro Takeda; Fumiyuki Kiuchi
Related Documents :
187229 - Disaggregation of hydroxyapatite crystals.
55409 - Light microscopic demonstration of myoid material in nuclei.
20356589 - Hyaluronic acid reagent suppressed endometriotic lesion formation in a mouse model.
405399 - A serum factor capable of stimulating hyaluronic acid synthesis in cultured rat fibrobl...
1366369 - Hyaluronic acid--a versatile biopolymer.
16253949 - Hyaluronan: pharmaceutical characterization and drug delivery.
25221789 - A new approach for the fabrication of microscale lipid bilayers at glass pipets: applic...
22680689 - The process experiment: exposure of amino acids in the expose-e experiment on the inter...
5459669 - Separation by gel chromatography of naturally occurring phosphatidylcholine mixtures ac...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-13
Journal Detail:
Title:  Journal of natural medicines     Volume:  -     ISSN:  1861-0293     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518405     Medline TA:  J Nat Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Three new triterpenoids from Panax ginseng exhibit cytotoxicity against human A549 and Hep-3B cell l...
Next Document:  Anti-inflammatory activity of diterpenes from Croton stellatopilosus on LPS-induced RAW264.7 cells.