Document Detail


Collagenase Clostridium histolyticum in patients with Dupuytren's contracture: results from POINT X, an open-label study of clinical and patient-reported outcomes.
MedLine Citation:
PMID:  24470559     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In POINT X, a study designed to reflect clinical practice and patient treatment choices, 254 European patients received open-label collagenase for Dupuytren's contracture. The most severely affected joint was treated first in 74% of patients. In total, 52%, 41%, 7%, and 1% of patients selected the little, ring, middle, and index finger, respectively; 79% had one or two joints treated. Only 9% of patients (n = 24) received 4 or 5 injections. The mean improvement in total passive extension deficit (TPED) was 34° on day 1, improving further by day 7 to 42°. This secondary improvement was maintained by day 90 and month 6. The mean number of injections/joint was 1.2 for the metacarpophalangeal joint and 1.25 for the proximal interphalangeal joint. Median time to recovery was 4 days; the mean improvement in hand function was clinically relevant as measured by the Unité Rhumatologique des Affections de la Main (URAM) score. In total, 87% and 86% of patients and physicians, respectively, were very satisfied or satisfied with treatment at month 6, although correlation between TPED and patient satisfaction was weak (Spearman -0.18, 95% CI -0.32 to -0.06). Collagenase was well tolerated, with 10 (3.9%) patients experiencing severe adverse events. As a real-world study, the POINT X findings can be generalized to the at-large population.
Authors:
D Warwick; M Arner; G Pajardi; B Reichert; Z Szabo; E H Masmejean; J Fores; D S Chapman; R A Gerber; F Huard; A Seghouani; P P Szczypa;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-26
Journal Detail:
Title:  The Journal of hand surgery, European volume     Volume:  -     ISSN:  2043-6289     ISO Abbreviation:  J Hand Surg Eur Vol     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315820     Medline TA:  J Hand Surg Eur Vol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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