Document Detail


Collagen turnover in the adult femoral mid-shaft: modeled from anthropogenic radiocarbon tracer measurements.
MedLine Citation:
PMID:  17405135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have measured the (14)C content of human femoral mid-shaft collagen to determine the dynamics of adult collagen turnover, using the sudden doubling and subsequent slow relaxation of global atmospheric (14)C content due to nuclear bomb testing in the 1960s and 1970s as a tracer. (14)C measurements were made on bone collagen from 67 individuals of both sexes who died in Australia in 1990-1993, spanning a range of ages at death from 40 to 97, and these measurements were compared with values predicted by an age-dependent turnover model. We found that the dataset could constrain models of collagen turnover, with the following outcomes: 1) Collagen turnover rate of females decreases, on average, from 4%/yr to 3%/yr from 20 to 80 years. Male collagen turnover rates average 1.5-3%/yr over the same period. 2) For both sexes the collagen turnover rate during adolescent growth is much higher (5-15%/yr at age 10-15 years), with males having a significantly higher turnover rate than have females, by up to a factor of 2. 3) Much of the variation in residual bomb (14)C in a person's bone can be attributed to individual variation in turnover rate, but of no more than about 30% of the average values for adults. 4) Human femoral bone collagen isotopically reflects an individual's diet over a much longer period of time than 10 years, including a substantial portion of collagen synthesised during adolescence.
Authors:
Robert E M Hedges; John G Clement; C David L Thomas; Tamsin C O'connell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physical anthropology     Volume:  133     ISSN:  0002-9483     ISO Abbreviation:  Am. J. Phys. Anthropol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400654     Medline TA:  Am J Phys Anthropol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  808-16     Citation Subset:  IM    
Affiliation:
Research Laboratory for Archaeology, University of Oxford, Oxford OX1 3QY, UK. robert.hedges@rlaha.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging / metabolism,  physiology
Bone Density / physiology*
Carbon Radioisotopes
Collagen / metabolism*
Female
Femur / metabolism*
Humans
Male
Middle Aged
Models, Biological*
Retrospective Studies
Sex Characteristics
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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