Document Detail

Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice.
MedLine Citation:
PMID:  25229861     Owner:  NLM     Status:  In-Data-Review    
Age-related skin thinning is correlated with a decrease in the content of collagen in the skin. Accumulating evidence suggests that collagen peptide (CP) and vitamin C (VC) transcriptionally upregulate type I collagen in vivo. However, the additive effects of CP and VC on age-related skin changes remain unclear. We herein demonstrate that CP and a VC derivative additively corrected age-related skin thinning via reduced oxidative damage in superoxide dismutase 1 (Sod1)-deficient mice. Co-treatment with these compounds significantly normalized the altered gene expression of Col1a1, Has2, and Ci1, a proton-coupled oligopeptide transporter, in Sod1(-/-) skin. The in vitro analyses further revealed that collagen oligopeptide, a digestive product of ingested CP, significantly promoted the bioactivity of the VC derivative with respect to the migration and proliferation of Sod1(-/-) fibroblasts. These findings suggest that combined treatment with CP and VC is effective in cases of age-related skin pathology.
Shuichi Shibuya; Yusuke Ozawa; Toshihiko Toda; Kenji Watanabe; Chisa Tometsuka; Takayuki Ogura; Yoh-Ichi Koyama; Takahiko Shimizu
Publication Detail:
Type:  Journal Article     Date:  2014-05-28
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  78     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-09-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1212-20     Citation Subset:  IM    
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