Document Detail


Collagen and the myocardium: fibrillar structure, biosynthesis and degradation in relation to hypertrophy and its regression.
MedLine Citation:
PMID:  2146489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extracellular matrix of the myocardium contains an elaborate structural matrix composed mainly of fibrillar types I and III collagen. This matrix is responsible for the support and alignment of myocytes and capillaries. Because of its alignment, location, configuration and tensile strength, relative to cardiac myocytes, the collagen matrix represents a major determinant of myocardial stiffness. Cardiac fibroblasts, not myocytes, contain the mRNA for these fibrillar collagens. In the hypertrophic remodeling of the myocardium that accompanies arterial hypertension, a progressive structural and biochemical remodeling of the matrix follows enhanced collagen gene expression. The resultant significant accumulation of collagen in the interstitium and around intramyocardial coronary arteries, or interstitial and perivascular fibrosis, represents a pathologic remodeling of the myocardium that compromises this normally efficient pump. This report reviews the structural nature, biosynthesis and degradation of collagen in the normal and hypertrophied myocardium. It suggests that interstitial heart disease, or the disproportionate growth of the extracellular matrix relative to myocyte hypertrophy, is an entity that merits greater understanding, particularly the factors regulating types I and III collagen gene expression and their degradation.
Authors:
M Eghbali; K T Weber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  96     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-14     Citation Subset:  IM    
Affiliation:
Cardiovascular Institute, Michael Reese Hospital, University of Chicago Pritzker School of Medicine, IL 60616.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / metabolism*,  pathology
Collagen / biosynthesis*,  chemistry,  genetics
Extracellular Matrix / metabolism
Gene Expression
Humans
Myocardium / metabolism*
Protein Denaturation
Grant Support
ID/Acronym/Agency:
R01-HL-31701/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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