Document Detail

Collagen in the transversalis fascia of patients with indirect inguinal hernia: a case-control study.
MedLine Citation:
PMID:  19095216     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to analyze the constituents of total and types I and III collagen fibers in the transversalis fascias of patients with indirect inguinal hernias, compared with samples removed from nonherniated cadavers.
METHODS: Biopsy samples from 26 patients and 26 cadavers were analyzed. Hematoxylin-eosin and picrosirius staining techniques were used. The images obtained were analyzed using a video morphometric technique to determine the constituents of total collagen and types I and III collagen in the transversalis fascia. The picrosirius-stained tissues were submitted to observation under polarized-light microscopy.
RESULTS: The results showed 17.3% less total collagen in patients with hernias compared with the control group (P < .01). Type I collagen in patients with indirect inguinal hernias was 23.7% less than the control group (P < .01), type III collagen was 6.4% less in the controls (P < .01).
CONCLUSION: The lower percentages of total collagen and type I collagen in the transversalis fascias of patients with indirect inguinal hernias could be a factor in hernia formation.
Antonio Britto Casanova; Eduardo Neubarth Trindade; Manoel Roberto Maciel Trindade
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2008-12-18
Journal Detail:
Title:  American journal of surgery     Volume:  198     ISSN:  1879-1883     ISO Abbreviation:  Am. J. Surg.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-16     Revised Date:  2012-05-02    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  AIM; IM    
Department of Surgery, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
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MeSH Terms
Collagen / analysis*
Fascia / chemistry*,  pathology
Hernia, Inguinal / etiology,  pathology*
Middle Aged
Retrospective Studies
Risk Factors
Young Adult
Reg. No./Substance:
Comment In:
Am J Surg. 2012 Apr;203(4):553-4   [PMID:  20630494 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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