Document Detail

Collagen in the esophageal mucosa of patients with progressive systemic sclerosis (PSS).
MedLine Citation:
PMID:  6084918     Owner:  NLM     Status:  MEDLINE    
Eighteen consecutive patients with an established diagnosis of Progressive Systemic Sclerosis (PSS) underwent different investigative procedures to determine possible esophageal involvement. Esophageal sclerosis was demonstrated by X-ray and manometry in 13 patients. In all patients endoscopic biopsies of esophageal mucosa were obtained. In all biopsies the concentrations of hydroxyproline, hydroxylysine and proline were determined. Patients suffering from PSS involving the esophagus were found to have a significantly higher concentration of collagen specific amino acids (hydroxyproline and hydroxylysine) in the esophageal mucosa (endoscopic obtainable biopsies) than patients with PSS not affecting the esophagus.
L Hendel; T Ammitzbøll; K Dirksen; M Petri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  64     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-10     Completed Date:  1985-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  480-4     Citation Subset:  IM    
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MeSH Terms
Collagen / physiology*
Esophagus / analysis*,  pathology
Middle Aged
Mucous Membrane / analysis
Scleroderma, Systemic / complications,  pathology*
Reg. No./Substance:

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