Document Detail

Collagen fiber and versican distribution within the lamina propria of fetal vocal folds.
MedLine Citation:
PMID:  18030168     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To analyze the presence and distribution of collagen fibers and versican in human vocal fold lamina propria of fetal larynges. STUDY DESIGN: Cross sectional analysis of cadaveric vocal folds of human fetuses. METHODS: Seven fetal larynges obtained from 28- to 36-week-old fetuses were analyzed with the Picrosirius-polarization method, immunohistochemistry, and image analysis. RESULTS: Collagen fibers within the lamina propria exhibited a monolaminar distribution pattern and spatial arrangement in "wicker basket." Versican distribution was larger in the superficial and intermediate layers when compared to the deep layer. CONCLUSION: Our findings suggest that collagen and versican distribution and arrangement within the lamina propria in the developing fetus are important for vocalization at birth.
Rogerio Borghi Buhler; Luiz U Sennes; Thais Mauad; Erich Christiano M Melo; Luiz Fernando F Silva; Paulo Hilário N Saldiva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-27     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Department of Otolaryngology, the University of São Paulo School of Medicine, São Paulo, Brazil.
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MeSH Terms
Collagen / metabolism*
Cross-Sectional Studies
Mucous Membrane / cytology,  metabolism*
Pregnancy Trimester, Third
Versicans / pharmacokinetics*
Vocal Cords / cytology*,  metabolism*
Reg. No./Substance:
126968-45-4/Versicans; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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