Document Detail

Collagen and elastin cross-linking: a mechanism of constrictive remodeling after arterial injury.
MedLine Citation:
PMID:  15951346     Owner:  NLM     Status:  MEDLINE    
Constrictive remodeling after arterial injury is related to collagen accumulation. Cross-linking has been shown to induce a scar process in cutaneous wound healing and is increased after arterial injury. We therefore evaluated the effect of cross-linking inhibition on qualitative and quantitative changes in collagen, elastin, and arterial remodeling after balloon injury in the atherosclerotic rabbit model. Atherosclerotic-like lesions were induced in femoral arteries of 28 New Zealand White rabbits by a combination of air desiccation and a high-cholesterol diet. After 1 mo, balloon angioplasty was performed in both femoral arteries. Fourteen rabbits were fed beta-aminopropionitrile (beta-APN, 100 mg/kg) and compared with 14 untreated animals. The remodeling index, i.e., the ratio of external elastic lamina at the lesion site to external elastic lamina at the reference site, was determined 4 wk after angioplasty for both groups. Pyridinoline was significantly decreased in arteries from beta-APN-treated animals compared with controls, confirming inhibition of collagen cross-linking: 0.30 (SD 0.03) and 0.52 (SD 0.02) mmol/mol hydroxyproline, respectively (P = 0.002). Scanning and transmission electron microscopy showed a profound disorganization of collagen fibers in arteries from beta-APN-treated animals. The remodeling index was significantly higher in beta-APN-treated than in control animals [1.1 (SD 0.3) vs. 0.8 (SD 0.3), P = 0.03], indicating favorable remodeling. Restenosis decreased by 33% in beta-APN-treated animals: 32% (SD 16) vs. 48% (SD 24) (P = 0.02). Neointimal collagen density was significantly lower in beta-APN-treated animals than in controls: 23.0% (SD 3.8) vs. 29.4% (SD 4.0) (P = 0.004). These findings suggest that collagen and elastin cross-linking plays a role in the healing process via constrictive remodeling and restenosis after balloon injury in the atherosclerotic rabbit model.
Camille Brasselet; Eric Durand; Faouzi Addad; Ayman Al Haj Zen; Mirjam B Smeets; Dominique Laurent-Maquin; Sylvie Bouthors; Georges Bellon; Dominique de Kleijn; Gaston Godeau; Roselyne Garnotel; Bruno Gogly; Antoine Lafont
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Publication Detail:
Type:  Journal Article     Date:  2005-06-10
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  289     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-12     Completed Date:  2005-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2228-33     Citation Subset:  IM    
INSERM E0016, Faculté de Médecine Paris V, Université René Descartes, France.
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MeSH Terms
Aminopropionitrile / pharmacology
Arteries / injuries,  metabolism*,  pathology*
Atherosclerosis / metabolism,  pathology
Balloon Dilatation
Collagen / chemistry,  metabolism*
Coronary Restenosis / metabolism,  pathology
Elastin / chemistry,  metabolism*
Enzyme Inhibitors / pharmacology
Extracellular Matrix / metabolism
Femoral Artery / injuries,  metabolism,  pathology
Microscopy, Electron, Transmission
Protein-Lysine 6-Oxidase / antagonists & inhibitors,  pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 151-18-8/Aminopropionitrile; 9007-34-5/Collagen; 9007-58-3/Elastin; EC 6-Oxidase

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