Document Detail

Collagen dysplasia in a litter of Garafiano shepherd dogs.
MedLine Citation:
PMID:  8940898     Owner:  NLM     Status:  MEDLINE    
A connective tissue disease resembling the human Ehlers-Danlos syndrome is reported in three Garafiano shepherd dogs from the same litter. The clinical signs included skin hyperextensibility and fragility, joint laxity, and ocular lesions. Microscopical studies showed abnormalities in the packing of collagen in fibrils and fibres in the skin. Systemic connective tissue defects were demonstrated in one necropsied puppy.
F Rodriguez; P Herráez; A Espinosa de los Monteros; P Calabuig; J L Rodríguez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Veterinärmedizin. Reihe A     Volume:  43     ISSN:  0514-7158     ISO Abbreviation:  Zentralbl Veterinarmed A     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331323     Medline TA:  Zentralbl Veterinarmed A     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Department of Histology and Pathological Anatomy, Veterinary Faculty, University of Las Palmas de Gran Canaria, Spain.
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MeSH Terms
Animals, Newborn / metabolism,  physiology*
Collagen / analysis,  metabolism,  ultrastructure
Collagen Diseases / complications,  diagnosis,  veterinary*
Connective Tissue Diseases / diagnosis,  physiopathology,  veterinary
Dog Diseases / diagnosis*,  pathology,  physiopathology*
Eye Diseases / etiology,  physiopathology,  veterinary
Joint Instability / etiology,  physiopathology,  veterinary
Lameness, Animal / etiology,  physiopathology
Microscopy, Electron / veterinary
Skin / chemistry,  metabolism,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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