| Collagen I confers gamma radiation resistance. | |
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MedLine Citation:
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PMID: 22705234 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The effect of collagen on the response of somatomammotroph tumor cells (GH3) to gamma, radiation therapy was studied in vitro. After incubating confluent GH3 cell monolayers in a serum-free, maintaining medium, either with or without collagen, the monolayers were irradiated with 137Cs, gamma radiation. Collagen reduces cell mortality via ERK1/2 activation, abolishing gamma radiation, cell death, and promotes cell invasion when acting in synergy with collagen and in association with the, MAPK/ERK1/2 signaling pathway activation. The presence of collagen in somatomammotroph tumors, confers resistance to radiation. |
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Authors:
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E Azorin; P R González-Martínez; J Azorin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-10 |
Journal Detail:
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Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: - ISSN: 1872-9800 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-6-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Technology Research Management, Nuclear Research National Institute, Dr. Nabor Carrillo Flores, Carr. México-Toluca S/N La Marquesa, 52750 Ocoyoacac, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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