Document Detail

Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy.
MedLine Citation:
PMID:  10829416     Owner:  NLM     Status:  MEDLINE    
Many substances are used in the production of biomaterials: metals (titanium), ceramics (alumina), synthetic polymers (polyurethanes, silicones, polyglycolic acid (PGA), polylactic acid (PLA), copolymers of lactic and glycolic acids (PLGA), polyanhydrides, polyorthoesters) and natural polymers (chitosan, glycosaminoglycans, collagen). With the rapid development in tissue engineering, these different biomaterials have been used as three-dimensional scaffolds and cell transplant devices. The principal biochemical and biological characteristics of the collagen-based biomaterials are presented, including their interactions with cells (fibroblasts), distinct from those of synthetic polymers, and their potential use in gene therapy through the formation of neo-organs or organoids.
B Chevallay; D Herbage
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  38     ISSN:  0140-0118     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-16     Completed Date:  2000-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  211-8     Citation Subset:  IM    
Institut de Biologie et Chimie des Protéines, UPR 412 CNRS, Lyon, France.
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MeSH Terms
Biocompatible Materials / chemistry*
Cell Culture Techniques / methods
Collagen / analogs & derivatives*
Culture Techniques / methods
Gene Therapy / methods
Reg. No./Substance:
0/Biocompatible Materials; 9007-34-5/Collagen

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