| Collaborative evaluation of antigen detection by a commercial latex agglutination test and enzyme immunoassay in the diagnosis of invasive candidiasis. | |
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MedLine Citation:
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PMID: 2179258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Cand-Tec Candida detection system and enzyme immunoassay for serum mannan were retrospectively compared in a controlled collaborative evaluation of antigen detection in 32 patients with candidiasis proven by biopsy or culture from a normally sterile site and with sera drawn within 7 days of inclusion. With a threshold titer of 1/8, which excluded false-positive results in 17 hospitalized patients without candidiasis, sensitivities for all 32 patients with candidiasis were 44% for the Cand-Tec assay and 17% for the enzyme immunoassay. Both assays provided greater sensitivity when sera were drawn within 24 h of inclusion in the study and in the category of patients with invasive candidiasis (57% by Cand-Tec and 33% by enzyme immunoassay). The Cand-Tec assay gave false-positive results (titer, greater than or equal to 1/8) in 4 of 6 patients with transient candidemia, in 1 of 20 otherwise healthy patients with rheumatoid factor, and in 1 patient with a positive cryptococcal latex agglutination test. Three serum specimens from 3 of 32 patients with candidiasis contained rheumatoid factor and gave titers of greater than or equal to 1/8 by the Cand-Tec assay. Detection of serum mannan by enzyme immunoassay was less sensitive but more specific than the Cand-Tec Candida detection system for the diagnosis of invasive candidiasis. |
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Authors:
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C Lemieux; G St-Germain; J Vincelette; L Kaufman; L de Repentigny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical microbiology Volume: 28 ISSN: 0095-1137 ISO Abbreviation: J. Clin. Microbiol. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-04-20 Completed Date: 1990-04-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505564 Medline TA: J Clin Microbiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 249-53 Citation Subset: IM |
Affiliation:
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Notre-Dame, Hospital, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Fungal
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blood Candida / immunology Candidiasis / blood, diagnosis*, immunology Evaluation Studies as Topic False Positive Reactions Humans Immunoenzyme Techniques* Latex Fixation Tests* Mannans / blood, immunology Opportunistic Infections / blood, diagnosis, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Fungal; 0/Mannans |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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