| Colesevelam HCl: a non-systemic lipid-altering drug. | |
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MedLine Citation:
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PMID: 12740000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colesevelam HCl (WelChol, Sankyo Pharmaceuticals Inc.) is a bile acid sequestrant polymer, which has been shown to significantly lower low density lipoprotein cholesterol and favourably affect high-density lipoprotein cholesterol blood levels in monotherapy and in combination with statins (HMG-CoA reductase inhibitors). Although it is similar to other bile acid sequestrants in that it binds bile acids and is non-systemic, colesevelam HCl differs in that it has a unique polymer structure that allows for greater tolerability with less potential drug interactions than with resins. Currently, statins are the most commonly prescribed lipid-altering drugs. However, it is not uncommon that patients demonstrate true or perceived intolerances to statin therapy, that are often dose-related and may include elevations in liver or muscle enzyme blood levels, or myalgias or muscle weakness without muscle enzyme elevation. In rare circumstances, myopathy and even rhabdomyolysis can occur with statins. In addition, many statins also have important potential drug interactions. Finally, statin monotherapy is often not sufficient in achieving lipid treatment goals in many severely dyslipidaemic patients and the availability of colesevelam HCl provides a lipid-altering treatment addition to other lipid-altering drugs. From a clinical perspective, such combination therapy is often required to achieve treatment goals [1] in patients with more complicated or severe dyslipidaemia. Colesevelam HCl may also be an alternative in monotherapy for many patients with mild-to-moderate hypercholesterolaemia, as well as in some patients at potential risk from systemic exposure to alternative lipid-altering drugs (such as young children and fertile women). |
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Authors:
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Harold Bays; Carlos Dujovne |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 4 ISSN: 1465-6566 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-12 Completed Date: 2003-07-22 Revised Date: 2008-04-14 |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 779-90 Citation Subset: IM |
Affiliation:
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Kansas Foundation for Clinical Pharmacology, Radiant Research, Kansas City, 12200 W 106th, Overland Park, KS 66215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allylamine*
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analogs & derivatives*,
metabolism,
pharmacokinetics,
therapeutic use Animals Antilipemic Agents* / metabolism, pharmacokinetics Child Clinical Trials as Topic Drug Interactions Female Half-Life Humans Hypercholesterolemia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 107-11-9/Allylamine; 182815-44-7/colesevelam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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