| Cold stress or a pyrogenic substance elevates thyrotropin-releasing hormone levels in the rat hypothalamus and induces thermogenic reactions. | |
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MedLine Citation:
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PMID: 2506482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both thyrotropin-releasing hormone (TRH) levels in the hypothalamus and thermoregulatory responses were assessed in rats after they had been equilibrated to each of three ambient temperatures (Ta: 8, 22 and 30 degrees C) tested. Cold exposure, in addition to elevating TRH levels in the hypothalamus, led to increased metabolism and cutaneous vasoconstriction in rats at Ta = 8 degrees C. In contrast, heat exposure resulted in decreased metabolism and cutaneous vasodilatation in rats accompanied by no change in hypothalamic TRH levels at Ta = 30 degrees C. In addition, rats were chronically implanted with a cerebroventricular cannula to allow administration of the pyrogenic substance polyriboinosinic acid-polyribocytidylic acis (Poly I:C) into the brain at Ta = 22 degrees C. Intracerebroventricular administration of Poly I:C, in addition to elevating hypothalamic TRH levels, produced a fever with a latency of onset of about 30 min. The fever induced by Poly I:C was brought about by increased metabolism and cutaneous vasoconstriction in rats. The results suggest that either cold stress or Poly I:C injection elevates TRH levels in rat hypothalamus and thus induces thermogenic reactions. |
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Authors:
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M T Lin; P S Wang; J Chuang; L J Fan; S J Won |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroendocrinology Volume: 50 ISSN: 0028-3835 ISO Abbreviation: Neuroendocrinology Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-10-26 Completed Date: 1989-10-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Affiliation:
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Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation* / drug effects Cold Temperature* Hypothalamus / analysis*, drug effects Injections, Intraventricular Male Poly I-C / pharmacology* Pyrogens* Rats Rats, Inbred Strains Skin / blood supply Stress, Physiological / physiopathology* Thyrotropin-Releasing Hormone / analysis* Vasoconstriction |
| Chemical | |
Reg. No./Substance:
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0/Pyrogens; 24305-27-9/Thyrotropin-Releasing Hormone; 24939-03-5/Poly I-C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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