Document Detail

Cold pressor test protocol to evaluate cardiac autonomic function.
MedLine Citation:
PMID:  16770350     Owner:  NLM     Status:  MEDLINE    
The primary objective of this study was to develop a cold pressor test (CPT) protocol to evaluate cardiac autonomic function. Secondary objectives were to assess CPT protocol reliability and to examine gender differences in response to orthostatic stress and the CPT. Healthy, normotensive men and women (n = 12 per group) completed 2 trials on different days in the left lateral decubitus and standing postures and during a 6 min CPT (hand immersion while seated). Measurements included R-R interval, blood pressure, ventilatory responses, spontaneous baroreflex sensitivity, and heart rate variability indices. During the CPT, blood pressure and the sympathetic nervous system (SNS) indicator increased significantly and low-frequency power, high-frequency power (normalized for tidal volume), and the parasympathetic nervous system (PNS) indicator decreased significantly. Standing caused significant increases in the SNS indicator and decreases in the R-R interval in both genders. The PNS indicator was higher in women than in men in the left lateral decubitus posture. The 6 min hand-immersion CPT provoked cardiac sympathetic activation and parasympathetic withdrawal; however, it is best suited to studies with a repeated measures design, as analysis of reliability suggests that responses are highly variable between individuals. Performing the CPT in the left lateral decubitus position may prevent vasovagal responses.
Jennifer L Wirch; Larry A Wolfe; Tracey L Weissgerber; Gregory A L Davies
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  31     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-10-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  235-43     Citation Subset:  IM    
Physical and Health Education, Queen's University, Kingston, ON, Canada.
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MeSH Terms
Autonomic Nervous System / physiology*
Clinical Protocols
Cold Temperature / diagnostic use*
Heart / physiology*
Heart Function Tests / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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