Document Detail

Cold-knife conization versus loop excision: histopathologic and clinical results of a randomized trial.
MedLine Citation:
PMID:  7835776     Owner:  NLM     Status:  MEDLINE    
Ninety patients with cervical intraepithelial neoplasia (CIN) were randomly assigned to loop excision (n = 38) or cold-knife conization (n = 52). All specimens were well evaluable at histology. The average width of the lesions at histology was 10.2 and 9.7 mm, respectively (ns). The average weight of the specimens was 2.6 and 5.6 g (P < 0.01) and the average depth was 9.2 and 15.8 mm (P < 0.01), respectively. The distance between the cervical resection margin and CIN was 14 mm after loop excision and 24 mm after cold-knife conization (P < 0.06). The margins of the specimen were not clear of disease in 8 patients after loop excision and in 12 patients after conization (ns). Two patients after loop excision and in three patients after cold-knife conization had postoperative bleeding. The results suggest that, compared with cold-knife conization, loop excision removes less healthy tissue without reducing the chances for cure.
F Girardi; M Heydarfadai; F Koroschetz; H Pickel; R Winter
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gynecologic oncology     Volume:  55     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-02-24     Completed Date:  1995-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  368-70     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Graz, Austria.
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MeSH Terms
Blood Loss, Surgical
Cervical Intraepithelial Neoplasia / pathology,  surgery*
Chi-Square Distribution
Cryosurgery* / adverse effects,  methods
Electrosurgery* / adverse effects,  methods
Prospective Studies
Uterine Cervical Neoplasms / pathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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