Document Detail

Cold-induced profuse sweating on back and chest. A new genetic entity?
MedLine Citation:
PMID:  82089     Owner:  NLM     Status:  MEDLINE    
Two sisters whose parents shared a grandfather had cold-induced sweating. Since childhood they had sweated profusely from the back and chest when exposed to environmental temperatures of 18 degrees to 7 degrees C. They had additional abnormalities--e.g., high palate and inability fully to extend the elbows--which neither their parents nor their sibs shared. The cold-induced sweating, which could not be stopped by a beta-adrenergic blocking agent, was abolished by postganglionic blockade with atropine sulphate. This indicates the possibility of a peripheral mechanism.
E Sohar; Y Shoenfeld; R Udassin; A Magazanik; M Revach
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1073-4     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Atropine / administration & dosage
Autonomic Fibers, Postganglionic / drug effects
Autonomic Nerve Block
Cold Temperature / adverse effects*
Eccrine Glands / drug effects,  secretion*
Hyperhidrosis / drug therapy,  genetics*
Propranolol / administration & dosage
Skin Temperature
Sweat Glands / secretion*
Reg. No./Substance:
51-55-8/Atropine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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