Document Detail

Cold and immobilization stress-induced changes in pain responsiveness and brain Met-enkephalin-like immunoreactivity in the rat.
MedLine Citation:
PMID:  3588347     Owner:  NLM     Status:  MEDLINE    
Pain responsiveness and Met-enkephalin-like immunoreactivity (MLI) were studied in the rat after cold (25 degrees C) and immobilization stress for different lengths of time (30 min, 90 min and 180 min). The 30-min stress-induced analgesia (as measured by the tail-flick method), which was partially antagonized by pretreatment with naloxone (5 mg/kg, SC), and the magnitude of this analgesia was less than that of the 90-min stress or 180-min stress. The 30-min stress resulted in a significant decrease in MLI in the mesolimbic area, striatum, hypothalamus and thalamus. After the 90-min stress, MLI was found to be significantly decreased in the prefrontal cortex, amygdaloid nuclei and piriform cortex, thalamus and hippocampus, while the 180-min stress failed to induce a significant change in any brain area tested. As such a change in MLI content was thought to be related to an increase in the activity of the endogenous Met-enkephalin neuronal system, the activation of this system by the stress, especially in the hypothalamus and thalamus, seemed to be associated with analgesia.
A Kurumaji; M Takashima; H Shibuya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Peptides     Volume:  8     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1987 Mar-Apr
Date Detail:
Created Date:  1987-07-17     Completed Date:  1987-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  355-9     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Cold Temperature
Enkephalin, Methionine / metabolism*
Naloxone / pharmacology
Pain / physiopathology*
Rats, Inbred Strains
Restraint, Physical
Stress, Physiological / physiopathology*
Stress, Psychological / physiopathology
Tissue Distribution
Reg. No./Substance:
465-65-6/Naloxone; 58569-55-4/Enkephalin, Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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