Document Detail


Cold but not sympathomimetics activates human brown adipose tissue in vivo.
MedLine Citation:
PMID:  22665804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As potential activators of brown adipose tissue (BAT), mild cold exposure and sympathomimetic drugs have been considered as treatments for obesity and diabetes, but whether they activate the same pathways is unknown. In 10 healthy human volunteers, we found that the sympathomimetic ephedrine raised blood pressure, heart rate, and energy expenditure, and increased multiple circulating metabolites, including glucose, insulin, and thyroid hormones. Cold exposure also increased blood pressure and energy expenditure, but decreased heart rate and had little effect on metabolites. Importantly, cold increased BAT activity as measured by (18)F-fluorodeoxyglucose PET-CT in every volunteer, whereas ephedrine failed to stimulate BAT. Thus, at doses leading to broad activation of the sympathetic nervous system, ephedrine does not stimulate BAT in humans. In contrast, mild cold exposure stimulates BAT energy expenditure with fewer other systemic effects, suggesting that cold activates specific sympathetic pathways. Agents that mimic cold activation of BAT could provide a promising approach to treating obesity while minimizing systemic effects.
Authors:
Aaron M Cypess; Yih-Chieh Chen; Cathy Sze; Ke Wang; Jeffrey English; Onyee Chan; Ashley R Holman; Ilan Tal; Matthew R Palmer; Gerald M Kolodny; C Ronald Kahn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-20     Completed Date:  2012-09-10     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10001-5     Citation Subset:  IM    
Affiliation:
Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / drug effects,  physiology*
Cold Temperature*
Epinephrine / pharmacology*
Humans
Positron-Emission Tomography and Computed Tomography
Sympathomimetics / pharmacology*
Grant Support
ID/Acronym/Agency:
DK033201/DK/NIDDK NIH HHS; DK046200/DK/NIDDK NIH HHS; DK055545/DK/NIDDK NIH HHS; DK081604/DK/NIDDK NIH HHS; DK087317/DK/NIDDK NIH HHS; K23 DK081604/DK/NIDDK NIH HHS; P30 DK036836/DK/NIDDK NIH HHS; RR025757/RR/NCRR NIH HHS; UL1 RR 025758/RR/NCRR NIH HHS; UL1RR025758/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Sympathomimetics; 51-43-4/Epinephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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