| Cold but not sympathomimetics activates human brown adipose tissue in vivo. | |
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MedLine Citation:
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PMID: 22665804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As potential activators of brown adipose tissue (BAT), mild cold exposure and sympathomimetic drugs have been considered as treatments for obesity and diabetes, but whether they activate the same pathways is unknown. In 10 healthy human volunteers, we found that the sympathomimetic ephedrine raised blood pressure, heart rate, and energy expenditure, and increased multiple circulating metabolites, including glucose, insulin, and thyroid hormones. Cold exposure also increased blood pressure and energy expenditure, but decreased heart rate and had little effect on metabolites. Importantly, cold increased BAT activity as measured by (18)F-fluorodeoxyglucose PET-CT in every volunteer, whereas ephedrine failed to stimulate BAT. Thus, at doses leading to broad activation of the sympathetic nervous system, ephedrine does not stimulate BAT in humans. In contrast, mild cold exposure stimulates BAT energy expenditure with fewer other systemic effects, suggesting that cold activates specific sympathetic pathways. Agents that mimic cold activation of BAT could provide a promising approach to treating obesity while minimizing systemic effects. |
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Authors:
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Aaron M Cypess; Yih-Chieh Chen; Cathy Sze; Ke Wang; Jeffrey English; Onyee Chan; Ashley R Holman; Ilan Tal; Matthew R Palmer; Gerald M Kolodny; C Ronald Kahn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-06-04 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-20 Completed Date: 2012-09-10 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 10001-5 Citation Subset: IM |
Affiliation:
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Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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drug effects,
physiology* Cold Temperature* Epinephrine / pharmacology* Humans Positron-Emission Tomography and Computed Tomography Sympathomimetics / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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DK033201/DK/NIDDK NIH HHS; DK046200/DK/NIDDK NIH HHS; DK055545/DK/NIDDK NIH HHS; DK081604/DK/NIDDK NIH HHS; DK087317/DK/NIDDK NIH HHS; P30 DK036836/DK/NIDDK NIH HHS; RR025757/RR/NCRR NIH HHS; UL1 RR 025758/RR/NCRR NIH HHS; UL1RR025758/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sympathomimetics; 51-43-4/Epinephrine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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