Document Detail

Cold air test: a simplified standard method for airway reactivity.
MedLine Citation:
PMID:  3094606     Owner:  NLM     Status:  MEDLINE    
A simple and standardized test has been developed to measure airway responsiveness to cold dry air. This consists of stepwise increases in ventilation of dry subfreezing air at 10, 20, 40 and 60% of predicted indirect maximum breathing capacity (IMBC). For each step, the inhalation time was 3 min. The optimal time between the steps was 5 min. Exposure ceased when either a fall in forced expiratory volume in one second (FEV1) of more than 20% of baseline occurred or when there was no response after breathing cold air at 60% predicted IMBC. Moderate isocapnic hyperventilation with cold air beyond 3 min induced no further bronchoconstriction. Varying the interval (0, 2 and 5 min) between the steps produced no significant differences in test results. Changing the pattern of breathing had no effect on airway responsiveness, provided that the patient maintained a constant minute-ventilation. This implies that it is not necessary to monitor the rate and depth of respiration continuously in order to achieve a given minute-ventilation, making the technique simpler. In addition, a "CO2 requirement graph" has been constructed at different levels of ventilation. This allows the inspired CO2 concentration to be preset, eliminating the need for elaborate equipment and monitoring of end-tidal CO2 to keep the subject isocapnic during hyperventilation.
B K Assoufi; M B Dally; A J Newman-Taylor; D M Denison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  22     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1986 Jul-Aug
Date Detail:
Created Date:  1986-12-02     Completed Date:  1986-12-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
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MeSH Terms
Asthma / physiopathology*
Bronchial Provocation Tests / methods*
Carbon Dioxide / physiology
Cold Temperature / diagnostic use*
Forced Expiratory Volume
Maximal Voluntary Ventilation
Middle Aged
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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