Document Detail

Cold acclimation in insulin secretion of isolated perfused pancreas of the rat.
MedLine Citation:
PMID:  7046458     Owner:  NLM     Status:  MEDLINE    
The secretory function of the endocrine and exocrine pancreas in the process of cold acclimation has been studied in rats fed at an ambient temperature of 2 degrees C. In anesthetized rats, plasma glucose decreased immediately after cold exposure and increased again toward the basal level after 20 days of continuous cold exposure. Plasma insulin level in these rats also decreased immediately after cold exposure, and the low level was maintained throughout the whole period of cold exposure. In the isolated perfused rat pancreas, the basal insulin output estimated before the stimulation with glucose decreased immediately after the cold exposure and increased gradually during the continuous cold exposure. In these preparations, the initial and the second phases of insulin output were induced by sustaining stimulation with 16.7 mM glucose. Changes in the glucose-induced initial and second phases showed a diphasic pattern during the course of cold exposure. Thus, there was temporary decrease within a week of cold exposure followed by a gradual increase after 3 wk of this condition. The diphasic insulin output in the preparation isolated from rats fed during cold exposure for 6 wk was twice as much as that in the preparation isolated from the rats fed during exposure to 23 degrees C for 5 wk. In the isolated perfused rat pancreas, a monophasic insulin output was induced by sustaining stimulation with 0.1 microM ACh. The monophasic insulin output showed an increasing tendency during cold exposure, but the increase was insignificant because of a larger individual variation.
E Harada; Y Habara; T Kanno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  242     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E360-7     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / pharmacology
Adaptation, Physiological*
Blood Glucose / analysis
Body Weight
Cold Temperature*
Insulin / blood,  secretion*
Pancreas / secretion*
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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