Document Detail


Cold Pressor Response in High Landers Versus Low Landers.
MedLine Citation:
PMID:  25478333     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Native high landers face two main environmental challenges i.e. hypobaric hypoxia and low ambient temperatures. Both factors contribute to increased sympathetic stimulation and increased blood pressure. Despite these challenges, subjects living at high altitude have lower systolic and diastolic pressures as compared to subjects living in plains. Present study investigated cold pressor test (CPT) which is a potential predictor of future hypertension in high landers and low landers Materials and Methods: Vascular reactivity in terms of changes in systolic and diastolic blood pressure and heart rate in response to cold pressor test has been compared in high lander (n=45) and low lander (n=46) population. Results: Systolic and diastolic blood pressure changes and heart rate changes with cold pressor test are lower in high landers as compared to low landers. Females in both the groups in general exhibited greater cold pressor response than males. Conclusion: Hypo-reactive cold pressor test is due to higher parasympathetic tone and lower sympathetic tone. Decreased cold pressor response in high landers reflects another adaptive modulation of sympatho-vagal activity that enables them to stay in hypobaric atmosphere and lower temperatures without undue autonomic stress.
Authors:
Jagdish Narayan; Archana Ghildiyal; Manish Goyal; Dileep Verma; Shraddha Singh; Sunita Tiwari
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-20
Journal Detail:
Title:  Journal of clinical and diagnostic research : JCDR     Volume:  8     ISSN:  2249-782X     ISO Abbreviation:  J Clin Diagn Res     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-12-5     Completed Date:  -     Revised Date:  2014-12-6    
Medline Journal Info:
Nlm Unique ID:  101488993     Medline TA:  J Clin Diagn Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  BC08-BC11     Citation Subset:  -    
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