Document Detail

Colchicine overdose: the devil is in the detail.
MedLine Citation:
PMID:  17277818     Owner:  NLM     Status:  MEDLINE    
Colchicine, a highly poisonous alkaloid, is a commonly used treatment for gout, Bechet's disease, and familial Mediterranean fever. Despite the knowledge of its side effects, the near universally fatal consequence of a significant overdose is commonly under-appreciated. In this report, we present a case series of 9 patients over the past 15 years (from within the Auckland region of New Zealand) that have presented with a colchicine overdose. Surprisingly, a significant number were accidental overdoses and all cases, apart from one, resulted in death. We question the current knowledge base about the toxicity of this drug amongst prescribers, patients, and their families and its use in the treatment of acute gout. Given its extremely narrow therapeutic index, should the manner in which medical practitioners prescribe this drug be reassessed?
Vikram Jayaprakash; Gillian Ansell; David Galler
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Publication Detail:
Type:  Journal Article     Date:  2007-01-26
Journal Detail:
Title:  The New Zealand medical journal     Volume:  120     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-02-08     Revised Date:  2007-06-05    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  U2402     Citation Subset:  IM    
Intensive Care Unit, Department of Anaesthesia, Middlemore Hospital, Otahuhu, Auckland.
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MeSH Terms
Colchicine / poisoning*
Dose-Response Relationship, Drug
Middle Aged
Reg. No./Substance:
Comment In:
N Z Med J. 2007;120(1252):U2503   [PMID:  17460750 ]
N Z Med J. 2007;120(1249):U2429   [PMID:  17308565 ]

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