| Colchicine affects the distribution of isotope-labeled H2O and extracellular markers in rat liver and hepatomas. | |
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MedLine Citation:
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PMID: 7037168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of hepatoma-bearing rats with colchicine (175 or 250 micrograms/100 g body wt) greatly diminished the radioactivity in tumors when measured 10 min after subcutaneous injection of 3H2O. There were relatively small effects of colchicine treatment on the level of radioactivity in blood and little change in the ratio of radioactivity in blood and liver. Inhibitory effects of colchicine were also observed for the distribution in hepatomas of the extracellular markers [3H] methoxy-inulin and [14C] sucrose. An effect of colchicine on circulation in hepatomas may be a factor in the previously reported inhibitory action on metabolite uptake. |
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Authors:
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M A Lea |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer letters Volume: 14 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 317-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colchicine / blood, pharmacology* Female Insulin / analogs & derivatives, metabolism Liver / drug effects*, metabolism Liver Neoplasms, Experimental / blood supply, metabolism* Male Neoplasm Transplantation Rats Rats, Inbred BUF Sucrose / metabolism Water / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA-16274/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 39289-45-7/insulin, methoxy-; 57-50-1/Sucrose; 64-86-8/Colchicine; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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